Dantrolene – A review of its pharmacology, therapeutic use and new developments T. Krause,1 M. U. Gerbershagen,2 M. Fiege,1 R. Weißhorn1 and F. Wappler3 1 Assistant Professor, 2 Staff Anaesthesiologist, 3 Professor of Anaesthesiology, Department of Anaesthesiology, University-Hospital Hamburg-Eppendorf, Hamburg, Germany Summary Human malignant hyperthermia is a life … The long road from the search for more tender pork to reversal of VF once again illustrates the importance that understanding underlying mechanisms can contribute to the … Because of blockage, there is decrease in release of calcium and decrease in spasm. Nevertheless, dantrolene could serve as a lead to other compounds with similar actions. Dantrolene is a muscle relaxant used for treatment of chronic spasticity that differs from other commonly used muscle relaxants in acting peripherally on muscle, rather than centrally on the spinal cord or brain. Spasms of the head and neck muscle spasms when they occur after spinal cord injury or stroke. However, its precise mechanism of action and its molecular targets are still incompletely known. Cells treated with dantrolene were electrically excitable but still exhibited significant reductions in contractility: Ellis deduced dantrolene’s site of action must lie a step beyond excitation of the cell membrane and the spread of this current into the T-tubules viz. Dantrolene sodium is thought to affect some step in the excitation-contraction coupling process. What are the side effects of Dantrolene (Dantrium)? MECHANISM OF ACTION: Dantrolene is structurally an imidazoline derivative and is classified as a direct acting muscle relaxant. Recent studies have identified the ryanodine receptor as a dantrolene‐binding site. Its primary action is on the contractile elements of the muscle.

Although some of its side effects such as mental depression, confusion, and dizziness suggest a CNS effect, a central antispasticity property of dantrolene has not been identified.
It, thus, prevents or reduces the increase in myoplasmic calcium ion concentration that activates the acute catabolic processes associated with malignant hyperthermia Dantrolene can cause acute liver injury which can be severe and even fatal. What type of spam is Dantrolene most effective in treating? What is the mechanism of action for Dantrolene? It directly relaxes muscle spasms by interfering with the release of calcium ions from storage areas inside skeletal muscles.
at the level of the intracellular calcium-release mechanism.

Mechanism of action of Dantrolene (Dantrolen): It acts directly on skeletal muscle by interfering with the release of calcium ion from the sarcoplasmic reticulum. Mechanism of Action It decreases the release of calcium from sarcoplasmic reticulum by binding to special type of calcium receptors, known as Ryanidine receptors.

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